Lambert-Eaton Myasthenic Syndrome

An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)

Also Known As:

Lambert-Eaton Syndrome; Eaton Lambert Syndrome; Syndrome, Lambert-Eaton; Syndrome, Lambert-Eaton Myasthenic; Eaton-Lambert Myasthenic Syndrome; Myasthenic-Myopathic Syndrome of Eaton-Lambert; Myasthenic-Myopathic Syndrome of Lambert-Eaton; Myopathic-Myasthenic Syndrome of Eaton-Lambert; Myopathic-Myasthenic Syndrome of Lambert-Eaton; Eaton Lambert Myasthenic Syndrome; Eaton-Lambert Myasthenic-Myopathic Syndrome; Eaton-Lambert Myopathic-Myasthenic Syndrome; Eaton-Lambert Myopathic-Myasthenic Syndromes; Lambert Eaton Myasthenic Syndrome; Lambert Eaton Syndrome; Lambert-Eaton Myasthenic-Myopathic Syndrome; Lambert-Eaton Myasthenic-Myopathic Syndromes; Lambert-Eaton Myopathic-Myasthenic Syndrome; Lambert-Eaton Myopathic-Myasthenic Syndromes; Myasthenic Myopathic Syndrome of Eaton Lambert; Myasthenic Myopathic Syndrome of Lambert Eaton; Myasthenic Syndrome, Eaton-Lambert; Myasthenic Syndrome, Lambert Eaton; Myopathic Myasthenic Syndrome of Eaton Lambert; Syndrome, Eaton-Lambert; Syndrome, Eaton-Lambert Myasthenic; Eaton-Lambert Syndrome; Myasthenic Syndrome, Lambert-Eaton

Neoplasms: 1361496
- Paraneoplastic Syndromes: 1109
  - Nervous System Paraneoplastic Syndromes: 132
    - Myasthenia Gravis: 8775
      - Lambert-Eaton Myasthenic Syndrome: 589
- Neoplasms by Site: 4
  - Nervous System Neoplasms: 237
    - Nervous System Paraneoplastic Syndromes: 132
      - Myasthenia Gravis: 8775
        Lambert-Eaton Myasthenic Syndrome: 589
Nervous System Diseases: 14737
- Neurodegenerative Diseases: 44095
  - Nervous System Paraneoplastic Syndromes: 132
    - Myasthenia Gravis: 8775
      - Lambert-Eaton Myasthenic Syndrome: 589
- Neuromuscular Diseases: 2048
  - Neuromuscular Junction Diseases: 85
    - Myasthenia Gravis: 8775
      - Lambert-Eaton Myasthenic Syndrome: 589
- Autoimmune Diseases of the Nervous System: 1576
  - Myasthenia Gravis: 8775
    - Lambert-Eaton Myasthenic Syndrome: 589
Immune System Diseases: 4430
- Autoimmune Diseases: 35458
  - Autoimmune Diseases of the Nervous System: 1576
    - Myasthenia Gravis: 8775
      - Lambert-Eaton Myasthenic Syndrome: 589

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Disease

Drug/Important Bio-Agent (IBA)